SCIENCE OF CANNABINOIDS
Cannabinoids are the chemical compounds within cannabis that are reported to relieve many ailments. Cannabinoids resemble endocannabinoids, compounds our bodies naturally produce to balance and control communication between cells. Researchers believe that unpleasant symptoms and diseases occur when a deficiency or problem affects the endocannabinoid system.
When cannabis is administered, cannabinoids bind to receptor sites in the brain and body. Cannabinoids have different effects based on which receptors they bind to. For example, CBN (Cannabinol) binds with CB-2 receptors located throughout the body, which may explain why patients report that it is a powerful analgesic. With an increasing understanding of the effects of cannabinoids, patients can now tailor their cannabinoid consumption to the type of relief they need.
Terpenes and terpenoids are the primary constituents of the essential oils of many types of plants and flowers. They give cannabis varieties their distinctive properties, aromas, and flavors. During the process of extracting essential oils from cannabis, terpenes are often lost. However, Mary’s strives to maintain or replenish vital terpenes in the creation of all of its products.
UNDERSTANDING BIOAVAILABILITY AND DOSING
Research shows that transdermal delivery is the most effective method of delivering cannabis to the body as it enters the blood stream directly. When smoked or eaten, patients may lose up to 70 percent of the cannabis consumed via air vaporization, metabolism and stomach acid, which is inefficient and makes accurate dosing difficult. Mary’s transdermal products are so effective that the dosing of a standard 10mg patch may be equivalent to that of an 80mg edible.
With optimized bioavailability, Mary’s products offer a reliable, consistent dosage. Like all medicines, an individual’s dosage is based on many factors such as age, body composition, diagnosis, etc. One patch is a typical dose for most patients, although some prefer to cut a patch into halves or even quarters, while others may use more than one patch to attain relief.